The Magolan Lab specializes in hit-to-lead medicinal chemistry, which is a key part of the complex and interdisciplinary process of discovery and development of new medicines. They synthesize small organic molecules with drug-like structural features including natural products and their derivatives. Working closely with biologists who evaluate these new compounds, they refine their chemical structures to achieve optimal biological properties and pharmaceutical potential, ultimately aiming to advance promising drug candidates into clinical trials.
The Magolan Lab develops new reactions and synthetic strategies that enhance the capacity of chemists to produce valuable specialty compounds from simpler, inexpensive building blocks. They focus mainly on three areas: 1) using sulfoxides and vinyl sulfides as versatile synthetic intermediates, 2) using environmentally benign heterogeneous reagents to simplify reactions and 3) efficiently preparing nitrogen-rich heterocyclic scaffolds with drug-like structural properties.