Leyla Soleymani
Associate Professor, Engineering Physics
(905) 525-9140 x 27204
Biosensors combine biorecognition elements such as nucleic acids, antibodies and their synthetic analogues with signal transduction elements for creating devices for analyzing biologically-relevant targets. In the context of infectious diseases, biosensors can be used for rapid detection of infection, identification of causative agents, and treatment selection, reducing the unnecessary and inappropriate use of antibiotics. At the Soleymani lab, we study the integration of smart molecular systems such as DNA/antibody assemblies and functional nucleic acids with electrical signal transduction mechanisms to find creative solutions for reagent-less and automated biosensing, in which molecular components are designed to do the work instead of the operator. The knowledge generated through this work has resulted in exciting platforms for the identification of bacterial species in native clinical samples without the need for bacterial growth cultures, target amplification, or addition of reagents, paving the way toward rapid testing.