Matthew Miller
Associate Professor, Biochemistry & Biomedical Sciences
(905) 525-9140 x 22387
Research in the Miller Laboratory is divided into three main areas of focus: Innate & Adaptive Immunity Upon infection, both the innate and adaptive immune system is mobilized to protect the host from virus-mediated pathologies. The Miller Lab focuses on understanding both the protective and harmful qualities of immune responses - essential information for developing novel vaccines and therapeutics. Influenza Virus Influenza A virus (IAV) presents a particularly formidable challenge to the adaptive immune system. The virus has specific properties that allow it to cause seasonal epidemics and periodic pandemics, which leads to current- generation IAV vaccines having to be administered seasonally, while providing optimal protection against only a very limited number of IAV strains. However, a new class of antibodies has recently been discovered which is capable of providing much more broad protection across multiple IAV subtypes. The Miller group is focused on understanding the immunobiology of these antibodies, how they are elicited, and how they may be useful for the generation of "universal" influenza virus vaccines and therapeutics. ALS Abnormal inflammation is a signature of many neurodegenerative diseases, yet the way in which inflammation contributes to the pathology of these diseases is poorly defined. The Miller Lab is working to understand the role of inflammation in the etiology of neurodegenerative diseases, with a specific focus on its role in amyotrophic lateral sclerosis (ALS).