Assistant Professor, Biochemistry & Biomedical Sciences
(905) 525-9140 x 21063
Antibiotics that cause damage to the bacterial genome do so in an effort to kill bacteria. However, like humans, bacteria are able to repair DNA damage and survive. In addition to promoting survival, these repair pathways may introduce mutations that lead to antimicrobial resistance. The Andres Lab is pursuing three major questions to understand how to combat antimicrobial resistance: 1. What is the molecular mechanism of DNA repair? 2. What differences exist in repair between bacterial species? 3. Can repair be inhibited to improve antimicrobial therapies? To answer these questions, researchers in the Andres Lab combine multiple approaches, integrating structural biology techniques with biochemistry and bacterial genetics. Some of their favourite structural techniques include small-angle x-ray scattering (SAXS), atomic force microscopy (AFM) and x-ray crystallography.