The Mla Pathway Plays an Essential Role in the Intrinsic Resistance of Burkholderia spp. to Antimicrobials
Several Burkholderia species are highly pathogenic and intrinsically resistant to multiple classes of antibiotics. However, manipulating the structure of their outer membranes could increase their sensitivity to treatment.
In a recent study, Postdoctoral Fellow Dr. Steve Bernier, Dr. Michael Surette, and Surette lab graduate student Susie Son show that the Mla pathway – a system involved in maintaining cell wall integrity – is genetically and functionally different within several species of Burkholderia in comparison to other proteobacteria.
Their results suggest that this pathway could represent an ideal genus-specific target to address Burkholderia’s intrinsic resistance to antimicrobials.
Read the full publication in the Journal of Bacteriology.
NewsRelated News
News Listing
Brighter World ➚
Researchers invent artificial intelligence model to design new superbug-fighting antibiotics
News
March 23, 2024
FHS News ➚
Decades of McMaster tuberculosis research leading to new prevention and control strategies
News
March 22, 2024