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Wright & Guitor Study ‘Antimicrobial Resistance and Respiratory Infections’

Co-author Allison Guitor is a PhD student within Dr. Gerry Wright’s lab at the Michael G. DeGroote Institute for Infectious Disease Research.

Antimicrobial resistance is a major global health issue. As respiratory infections remain one of the leading causes of death worldwide, increased rates in resistant respiratory pathogens are of particular concern.

In a recent review accepted in Chest entitled “Antimicrobial Resistance and Respiratory Infections”, IIDR’s Dr. Gerry Wright and PhD student Allison Guitor discuss the various ways in which respiratory bacteria can avoid or overcome antibiotics.

Their study further presents some of the more recently discovered resistance mechanisms that are already or may become prevalent in respiratory infections, including the well-known and extensively studied β-lactamases, efflux systems, and antibiotic-modifying enzymes and target-modifying proteins, among others.

Finally, the authors highlight other important aspects of antimicrobial resistance, such as how resistance develops and spreads, how mechanisms of resistance can be detected through various methods, and how the environment and respiratory microbiome may play an important role in increasing the rise of antibiotic resistance.